Arsenic-induced Histological Alterations in Various Organs of Mice.
نویسندگان
چکیده
Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well documented yet. Swiss albino male mice were divided into 2 groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite at 10 mg/kg b.w. orally for 8 wks). Group 2 showed marked degenerative changes in kidney, liver, thoracic artery, and brain whereas Group 1 did not reveal any abnormalities on histopathology. We therefore concluded that arsenic induces histological alterations in the tested organs.
منابع مشابه
Post-treatment effects of Alstonia scholaris extract against radiation-induced biochemical alterations in Swiss albino mice
Background: This study has been undertaken to find out the possible radioprotective potential of the Alstonia scholaris extract (ASE). Materials and Methods: For experimental study, healthy Swiss albino male mice were selected from an inbred colony and divided in four groups. Group I (normal) did not receive any treatment. Group II was orally supplemented ASE once daily at the dose of ...
متن کاملAlterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
متن کاملTesticular stereological and histological changes in an experimental murine model of visceral leishmaniasis
Background and Aim: Visceral leishmaniasis, a native disease in developing countries, can cause functional impairment in various organs, including the reproductive system, which can lead to infertility. The aim of this study was to evaluate the stereological, morphometric and morphological changes of testicular histoarchitecture in an experimental murine model of visceral leishmaniasis in BALB/...
متن کاملPost treatment effect of Grewia asiatica against radiation induced biochemical changes in brain of Swiss albino mice
Background: The aim of the present study was to evaluate the radioprotective effect of Grewia asiatica fruit pulp extract (GAE) on Swiss albino mice exposed to gamma radiation. In the present study radioprotective efficacy of Grewia asiatica (rich in anthocyanin, carotenes, vitamin C, etc.) was studied against radiation induced biochemical alterations in mice cerebrum. Materials and Methods: Fo...
متن کاملPositive effects of Vitamin C in arsenic trioxide and sodium fluoride induced genotoxicity and oxidative stress in mice in vivo
The aim of the present study was to evaluate Vitamin C (VC) as a potent natural antioxidant to mitigate the genotoxic effects of Arsenic trioxide and sodium fluoride in Swiss albino mice in vivo. The study was divided into eight groups consisting of control treated with normal saline (Group I), Group II, III, IV, V, VI, VII and the VC group with only Vitamin C (500 mg/kgbw). Arsenic trioxide (4...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of cytology & histology
دوره 6 3 شماره
صفحات -
تاریخ انتشار 2015